L. Synoradzki, A. Janczewski, M. Włostowski
2005
Citations
1
Influential Citations
12
Citations
Journal
Organic Process Research & Development
Abstract
We investigated the reaction of alkylation of 2-phthalimidoethanol with ethyl chloroacetate leading to ethyl(2-phthalimidoethoxy)acetate. The synthesis was successfully optimised by applying factorial design. Major side products have been separated, identified, and characterised. The yield level was increased from 25% to 52%, and a method of decreasing the amount of side products has been proposed.