Zheng Guo-jun
2012
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Chemical Reagents
Abstract
Starting with 5-nitroisophthalic acid,the intermediate compound 5-(acetamido)-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiono-1,3-benzenedicarboxamide was obtained by several steps reaction such as esterification,reduction,iodination,acylation successively.And then,iohexol was obtained by coupling glycidol with the above-mentioned compound.The target product and related impurities based onstandard of Pharmacopoeia.The process is simple and suitable for industrial production.