L. Gan
2011
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Journal
Chemistry World
Abstract
The synthesis technology of α-(chloromethyl)-2,4-dichlorobenzyl alcohol,a useful antifungal agent,was optimized.Orthogonal test was used to study the effect of the amount of aluminium chloride hexahydrate,amount of alcohol,reaction temperature and reaction time on the yield.When the amount of 2,2′,4′-trichloroacetophenone was 30 g,aluminium chloride was 1 g,aluminium isopropoxide was 10 g,alcohol was 90 mL,reaction temperature was 60 ℃ and reaction time was 4 h,the yield reached 99.5%.The new method has the advantages of convenient operation,mild reaction conditions and cheap reagents.This method is suitable for industrial process.