Li Sheng-song
2010
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Journal
Chemistry & Bioengineering
Abstract
The synthetic technology of 3,5-dichloro-2,6-difluoropyridin-4-amine with pentachloropyridine as raw material was improved,and the effects of influential factors on yield of 3,5-dichloro-2,6-difluoropyridin-4-amine were studied.Under anhydrous fluorination reaction condition and fluorination reaction temperature of 100~158℃,the yield of the intermediate 3,5-dichloro-2,4,6-trifluoropyridine was over 80%,and the total yield of the product was 70.4%.It′s unnecessary to dry undydrous KF in baking oven or to seperate the fluorinated product by fractionating tower.Furthurmore,the ammoniation reaction occured at room temperature,so the apparatus bearing high temperature and pressure were not required.The improved technology,which had simple operation,mild reaction condition,small investment and low cost,was proved to possess high application prospect.