N. Rahman, S. Haque, S. N. H. Azmi
2017
Citations
1
Influential Citations
21
Citations
Journal
Journal of Saudi Chemical Society
Abstract
Abstract Two optimized and validated spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in commercial dosage forms. Method A is based on the reaction of tertiary amino group of the drug with N -bromosuccinimide in methanol–acetone medium resulting in the formation of a yellow colored product, which absorbed maximally at 353 nm. Method B involves the formation of a colored chloroform extractable ion-pair complex of the drug with bromothymol blue at pH 2.32 absorbing maximally at 400 nm. Beer’s law is obeyed in the concentration ranges 50–600 and 2–55 μg mL −1 with molar absorptivity of 1.58 × 10 2 and 1.50 × 10 4 L mol −1 cm −1 for methods A and B, respectively. The regression analysis yields the calibration equations: A = 4.012 × 10 −4 + 1.16 × 10 −3 C and A = 9.612 × 10 −4 + 2.198 × 10 −2 C for methods A and B, respectively. The application of the proposed methods to commercial dosage forms is presented.