Wang Xiu-lan
2007
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Journal
Journal of Taiyuan University of Technology
Abstract
Uniform experiment design was applied in carrying on the experiment.The important intermediate of tramadol hydrochloride: 2-(dimethylamino) methyl cyclohexanone was synthesized with the Mannich reaction.Simultaneously,adopting regression analysis and Monte Carlo simulated obtained the optimum reaction conditions:cyclohexanone:polyformaldehyde: dimethylamine hydrochloride=2.1∶1∶1(molar ratio),react ion temperature is 95℃,react ion time is 2.7 hours.The yield of 2-(dimethylamino)methyl cyclohexanone can reach 75.1%.The product is analyzed qualitatively by means of IR and 1HNMR.