H. D. Brahmachari, K. T. Augusti
Sep 1, 1962
Citations
0
Influential Citations
28
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Of the methyl substituted procaine congeners, 2-diethylaminoethyl-3 5-dimethylbenzoate hydrochloride was most effective having a therapeutic index of 64.1 and a protective index of 28.5. 2-Diethylaminoethyl-2,3-dimethylbenzoate hydrochloride and 2-diethylaminoethyl-2,3,5,6-tetramethylbenzoate hydrochloride had higher protective indices, but lower therapeutic indices compared with procaine hydrochloride. Compared with procaine hydrochloride, 2-diethylaminoethyl-2,5-dimethylbenzoate hydrochloride has slightly higher therapeutic index (37.4), but a much higher protective index. The present study reveals that methyl substitution at position 3 and 5 in the benzene ring of procaine yields a compound which has much higher protective and therapeutic indices compared with the parent substance procaine. Acknowledgement. We thank the Director, A.I.I.M.S. for facilities, the I.C.M.R. for financial support, Messrs. McNeil Laboratories for some of the procaine congeners, Messrs. Parke Davis and Co. for phenytoin sodium, Messrs. Knoll for Metrazol and Mr. T. N. Sugathan for the statistical analysis. Department of Pharmacology, KANTI KAPILA. All-India Institute of Medical Sciences, New Delhi-16, India. February 13, 1962. R. B. ARORA.