V. V. Shinde, Y. Jeong
Jul 21, 2016
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron
Abstract
Abstract Novel tricyclic pyrimido[1,2-b]indazole-3-carbonitrile derivatives containing both biologically active pyrimidine and indazole templates are synthesized by three-component reaction of 1 H -indazol-3-amine, aldehydes, and malononitrile catalyzed by base di- n -butylamine (DBA) in ethanol. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purifications.