Mingliang Zhang, Deng Yue, Zhen-Hua Wang
Feb 16, 2016
Citations
0
Influential Citations
14
Citations
Journal
Beilstein Journal of Organic Chemistry
Abstract
For the first time, a catalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones was achieved with a chiral bifunctional amine-thiourea as a catalyst possessing multiple hydrogen-bond donors. With this developed method, a range of 3-hydroxy-3-nitromethyl-1H-pyrrol-2(3H)-ones bearing quaternary stereocenters were obtained in acceptable yield (up to 75%) and enantioselectivity (up to 73% ee).