M. Swami, R. Singh
May 14, 2008
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Quality indicators
Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
In the search for the better fungicides, bactericides and antiandrogen agents, studies have been carried out to assess the growth-inhibiting potential of the newly synthesized organogermanium(IV) complexes against various pathogenic fungal and bacterial strains as well as on reproductive organs of the male albino rats. The results of these studies have been compared with the standard fungicide Bavistin and bactericide Streptomycin. The studies demonstrate that the ligands and their trimethylgermanium(IV) complexes have comparable antimicrobial activity. The results also indicated that the weights of the body and vital organs were not affected after the treatment suggesting that the complexes have no side effect or toxicological effect and maintained normal physiology of the animals throughout the experiment. It has also been revealed that the organogermanium(IV) complexes showed more antifertility effect than the bases. These complexes were synthesized by the reactions of trimethylgermanium(IV) chloride with biologically potent N∪SH donor bases and characterized by elemental analyses, conductance measurements, molecular weight determinations and IR, 1 H NMR, 13 C NMR and electronic spectral studies.