R. Larock, F. Kondo, K. Narayanan
1989
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Prostaglandin E 2 is synthesized by an efficient two step sequence involving (1) preparation of ketol 4 via vinylpalladation of 4-cyclopentene-1,3-diol using either vinylmercurial 1 or vinylic iodide 5 , and (2) subsequent regio- and stereoselective alkylation via sequential dianion generation, tin enolate formation, and organic halide addition.