P. L. Nayak, M. L. Bender
Aug 14, 1978
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0
Influential Citations
19
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract Four ethyl p -nitrophenyl alkylphosphonates were studied for the inhibition of elastase. A pH-dependence study using the assay substrate BOC-Ala-ONp or the phosphonate inhibitors showed the participation of an ionizing group with an apparent pKa of 6.9 and a decrease of reaction or inhibition at higher pH. Out of the four compounds investigated ethyl p -nitrophenyl pentylphosphonate was found to be the best inhibitor of elastase as judged from the value of k 2 K I . This value, which is the measure of inhibitory capacity, is the highest reported so far for the inhibition of elastase.