K. Waisser, Josef Matyk, Hana Divišová
May 1, 2007
Citations
1
Influential Citations
15
Citations
Quality indicators
Journal
Archiv der Pharmazie
Abstract
Based on our previous studies, 21 new halogenated 3‐(4‐alkylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐diones were synthesized by the reaction of salicylanilides and methyl‐chloroformate. All compounds were screened in vitro against three different strains of mycobacterium, and Free‐Wilson method was used to establish structure‐activity relationships. 6‐Bromo‐3‐(4‐butylphenyl)‐1,3‐benzoxazine‐2,4‐(3H)‐dione 3b proved to be the most active compound of the series.