D. Lowe, J. M. Turner
Nov 1, 1970
Citations
0
Influential Citations
10
Citations
Journal
Journal of general microbiology
Abstract
SUMMARY: i-Aminopropan-2-ol is a component of vitamin B12 (Cooley, Ellis P Hodgkin, 1958). The metabolic origin of the nitrogen atom of d-i-aminopropan-2-ol in vitamin B12 was established using [15N]-l-threonine, added to the growth medium of Streptomyces griseus (Krasna, Rosenblum S Dekker S Lowe &Turner, 1968) revived interest in the possibility that the free amino alcohol, formed from l-threonine via aminoacetone, served as a precursor. The roles of l-threonine and d-i-aminopropan-2-ol in vitamin B12 biosynthesis by a Streptomyces strain were therefore investigated using 14C-labelled compounds.