E. Kantchev
Sep 27, 2011
Citations
0
Influential Citations
38
Citations
Journal
Chemical communications
Abstract
A density functional theory study of the addition of phenylboronic acid to cyclohexenone catalyzed by chiral 1,4-diene-Rh(I) catalyst reveals that 1,4-addition is thermodynamically preferred. The enthalpy-driven enantioselection occurs during the carborhodation step and not the enone binding step, as previously proposed. The chiral ligand selectively destabilizes the disfavored transition state by making it "more early".