V. A. Penniyaynen, A. V. Kipenko, E. Lopatina
Feb 1, 2013
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Journal
Bulletin of Experimental Biology and Medicine
Abstract
Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouabagenin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin mediate their inhibitory effect on the skin growth via interaction with α1-isoform of Na+,K+-ATPase that plays mostly the role of ionic pump.