吴佳佳, 季程宇, 谢童杰
Aug 30, 2017
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Journal
Hans Journal of Chemical Engineering and Technology
Abstract
(S)-3-甲基氨基-1-(噻吩-2-基)丙醇是抗抑郁药度洛西汀的重要中间体。本文根据起始原料的不同,将其合成方法概括为:乙酰噻吩法、噻吩法和噻吩甲醛法,分析了各种方法的工艺特点,并指出了(S)-3-甲基氨基-1-(噻吩-2-基)丙醇未来的发展趋势。 (S)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol is a class of important intermediate for anti-depressant R-Duloxetine. This paper summarized several methods to synthetize the compound according to its starting materials: starting from acetylthiophene, starting from thiophene, start-ing from thiophenecarboxaldehyde. The features of each method were analyzed. Finally, the de-velopment in the synthesis technology of (S)-3-(Methylamino)-1-(thiophen-2-yl) propan-1-ol was proposed.