K. Miyamoto, H. Ohta
May 1, 1992
Citations
0
Influential Citations
18
Citations
Journal
Biotechnology Letters
Abstract
SummaryThe metabolic pathway of phenylmalonic acid byAlcaligenesbronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of α-aryl-α-methylmalonic acids to α-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (±)-mandelic acid withA.bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.