H. Alvarez, Joyce L. de Andrade, N. Pereira
Sep 1, 2007
Citations
1
Influential Citations
17
Citations
Journal
Catalysis Communications
Abstract
Abstract 1,2-methylenedioxy-4(1-propenyl)benzene, isosafrol ( 1a) , is an important intermediate for the synthesis of drugs like L-DOPA. In this work, different vanadium complexes have been evaluated as catalysts for the preparation of the corresponding double bond cleavage product, 3,4-methylenedioxybenzaldehyde, piperonal ( 2 ), and the corresponding epoxide, 2-methyl-3-[3′,4′-methylenedioxyphenyl]oxirane ( 3 ). When VCl 2 (salen) is used either with H 2 O 2 60% or TBHP (5 M isooctane solution), the epoxide was the major product obtained in very good yields.