W. Hummel, Mutlu Kuzu, B. Geueke
Sep 4, 2003
Citations
3
Influential Citations
58
Citations
Journal
Organic letters
Abstract
[reaction: see text] d-tert-Leucine was prepared with an enantiomeric excess of >99% by an enzyme-catalyzed oxidative resolution of the racemic mixture of dl-tert-leucine with use of leucine dehydrogenase. The l-amino acid was oxidized completely due to coupling of the primary reaction with a highly efficient irreversible NAD(+)-regenerating step by NADH oxidase.