J. Cooper, I. Melcer
Jun 1, 1961
Citations
1
Influential Citations
95
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Journal
The Journal of pharmacology and experimental therapeutics
Abstract
The enzyme system catalyzing the hydroxylation of tryptophan to 5-hydroxytryptophan has been isolated from the particulate fraction of the intestinal mucosal cells of the rat and guinea pig. The hydroxylation reaction requires ascorbic acid or its analogs and Cu ++ for activity, appears to function anaerobically, and is inhibited by the soluble fraction of the intestinal mucosal cell.