Yuki Kawamata, Ming Yan, Zhiqing Liu
May 16, 2017
Citations
0
Influential Citations
264
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
A practical electrochemical oxidation of unactivated C–H bonds is presented. This reaction utilizes a simple redox mediator, quinuclidine, with inexpensive carbon and nickel electrodes to selectively functionalize “deep-seated” methylene and methine moieties. The process exhibits a broad scope and good functional group compatibility. The scalability, as illustrated by a 50 g scale oxidation of sclareolide, bodes well for immediate and widespread adoption.