Isita Jhulki, Prem K. Chanani, Sameh H Abdelwahed
Jun 29, 2016
Citations
1
Influential Citations
19
Citations
Journal
Journal of the American Chemical Society
Abstract
Roseoflavin is a naturally occurring riboflavin analogue with antibiotic properties. It is biosynthesized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group. Herein we report the identification of a flavin-dependent enzyme that converts flavin mononucleotide (FMN) and glutamate to 8-amino-FMN via the intermediacy of 8-formyl-FMN. A mechanistic proposal for this remarkable transformation is proposed.