Nikhil U. Mohe, K. Padiya, M. Salunkhe
Apr 1, 2003
Citations
1
Influential Citations
8
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
The mixture of carbon tetrachloride, N-methyl morpholine (NMM), pyridine and water in acetonitrile has been exploited for the oxidation of dinucleoside H-phosphonate diesters to the corresponding phosphates. The system is found to be inert to the phosphoramidate (P-N) and the phosphorothioate (P-S) linkages and has successfully been applied to the solid phase synthesis of mixed-backbone oligonucleotides (MBOs).