Kui Dong, Haitao Qin, Xing-Xing Bao
Sep 25, 2014
Citations
0
Influential Citations
39
Citations
Journal
Organic letters
Abstract
A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported.