D. R. Davies, P. Holland
Dec 1, 1972
Citations
0
Influential Citations
35
Citations
Journal
Biochemical pharmacology
Abstract
Abstract The oximes, 2-hydroxyiminomethyl- N -methylpyridinium methyl methane-sulphonate (P2S) and the dodecyl iodide salt (PAD) and atropine sulphate have been shown to be without effect upon the development of delayed neurotoxic signs in chickens after poisoning by diisopropyl phosphorofluoridate (DFP). The production of delayed neurotoxic signs by repeated sub-neurotoxic doses of DFP and isopropyl methyl-phosphonofluoridate (Sarin) and the effect of varying the time interval between these doses have been demonstrated in chickens. Sub-neurotoxic doses of DFP and Sarin appear to be additive in their action and the interval between successive intoxications may be quite long—16 days with DFP.