J. Coste, E. Frérot, P. Jouin
Apr 22, 1991
Citations
0
Influential Citations
124
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract The main product of N-methylated amino acid coupling, when oxybenzotriazole is present in the reagent (BOP, PyBOP, HBPyU) or as an additive (DCC/HOBt), is the weakly reactive benzotriazolyl ester. On the other hand, the corresponding new halogenated reagents PyBroP, PyCloP and PyClU give very good results and can be recommended.