K. Wynne, Adrian J. Park, C. Small
Apr 18, 2006
Citations
11
Influential Citations
321
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Quality indicators
Journal
International Journal of Obesity
Abstract
Background:Oxyntomodulin has recently been found to decrease body-weight in obese humans and may be a potential anti-obesity therapy.Objective:To determine whether oxyntomodulin alters energy expenditure, in addition to reducing energy intake, in ‘free-living’ overweight and obese volunteers.Design:Randomized double-blind controlled cross-over trial.Setting:Community and hospital-based.Participants:Fifteen healthy overweight and obese men and women (age: 23–49 years, BMI: 25.1–39.0 kg/m2). All volunteers completed the study protocol.Interventions:Four-day subcutaneous self-administration of pre-prandial oxyntomodulin, three times daily. Participants were advised to maintain their normal dietary and exercise regimen.Measurements:(1) Energy expenditure, measured by indirect calorimetry and combined heart rate and movement monitoring; (2) energy intake, measured during a study meal.Results:Oxyntomodulin administration reduced energy intake at the study meal by 128±29 kcal (P=0.0006) or 17.3±5.5% (P=0.0071), with no change in meal palatability. Oxyntomodulin did not alter resting energy expenditure; but increased activity-related energy expenditure by 143±109 kcal/day or 26.2±9.9% (P=0.0221); total energy expenditure by 9.4±4.8% (P=0.0454) and physical activity level by 9.5±4.6% (P=0.0495). A reduction in body weight of 0.5±0.2% was observed during the oxyntomodulin administration period (P=0.0232).Conclusion:Oxyntomodulin increases energy expenditure while reducing energy intake resulting in negative energy balance. This data supports the role of oxyntomodulin as a potential anti-obesity therapy.