W. Havener, H. Falls
Oct 1, 1954
Citations
0
Influential Citations
3
Citations
Journal
A.M.A. archives of ophthalmology
Abstract
OXYPHENONIUM (Antrenyl), a synthetic quaternary ammonium salt (diethyl [2-hydroxyethyl] methylammonium bromide α-phenylcyclohexaneglycolate), is a powerful mydriatic and cycloplegic drug. Its anticholinergic pharmacologic effects are essentially the same as those of atropine and are obtainable with approximately the same concentration of drug. 1 Oxyphenonium is stable in tablet or solution and may be administered topically, orally, or parenterally. It is freely soluble in water and almost completely insoluble in nonpolar solvents. Oxyphenonium has been used clinically in the therapy of peptic ulcer and allied digestive disorders 2 and as a preanesthetic medication. LABORATORY EVALUATION OF OXYPHENONIUM Excellent mydriasis, persisting for four to eight days, is produced in adult albino rabbits by a single ocular instillation of one drop of 5% oxyphenonium bromide in 1: 5,000 benzalkonium (Zephiran) chloride. This mydriasis is complete within an hour. A 1% oxyphenonium solution produces complete mydriasis for two days, with return to normal by the