A. Tewari, M. Hein, A. Zapf
Oct 10, 2005
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75
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Journal
Tetrahedron
Abstract
Abstract Alkyl-di-(1-adamantyl)phosphonium salts are practical ligand precursors for the palladium-catalyzed amination of aryl chlorides. In the presence of typically 0.5 mol% Pd(OAc)2 and 1 mol% of ligand precursor a variety of activated and deactivated aryl chlorides can be aminated in good to excellent yield (73–99%). Applying optimized conditions catalyst turnover numbers up to 10,000 have been achieved.