Komal Rizwan, Idris Karakaya, M. Zubair
Jun 1, 2022
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Journal
Journal of Sulfur Chemistry
Abstract
Bi-aryl ketones are important motifs in large number of pharmaceutical compounds and natural products. A protocol for the synthesis of thienyl ketones has been developed via Pd (0) catalyzed cross-coupling reaction. The desired thienyl ketones (3a-x) were synthesized by cross coupling of 3-methylthiophene-2-carbonyl chloride with variety of aryl/heteroaryl-boronic acids in good to excellent yields (46–91%) under mild conditions (1.5 eq Cs2CO3 at 50 °C). Different functional groups were well tolerated under the developed reaction conditions. GRAPHICAL ABSTRACT