Nurul H. Ansari, Serge R. Banini, Matthew M. Cummings
Mar 4, 2020
Citations
0
Influential Citations
4
Citations
Journal
The Journal of organic chemistry
Abstract
A flexible route to both symmetrical and unsymmetrical 1H,8H-pyrrolo[3,2-g]indole has been developed. The key and ultimate step is a double palladium catalyzed, carbon monoxide mediated reductive cyclization of 1,4-dialkenyl-2,3-dinitrobenzenes. The cyclization precursors were prepared either by a double Kosugi-Migita-Stille cross coupling of 1,4-dibromo-2,3-dinitrobenzene with an alkenyltin reagent to give symmetrical products. Unsymetrical cyclization precursors were prepared by two sequential cross couplings using 4-iodo-2,3-dinitrophenyl triflouromethanesulfonate as the starting material.