Scuhand Basuli, G. Satyanarayana
Feb 28, 2018
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0
Influential Citations
6
Citations
Journal
European Journal of Organic Chemistry
Abstract
[Pd]-catalyzed direct acylation of iodoacetanilides/iodophenyl acetates with aldehydes, was presented. Simple bench-top aldehydes were used as the non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without the directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones via acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.