Jérémie Fournier dit Chabert, Lionel Joucla, E. David
Mar 29, 2004
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Influential Citations
79
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Journal
Tetrahedron
Abstract
Abstract Straightforward and rapid access to 2-arylbenzo[ b ]thiophenes has been developed. It involved a catalytic coupling of 3-activated benzo[ b ]thiophenes with several aryl halides in the presence of a phosphine-free palladium system. In case of fragile functional groups such as aldehydes, a quaternary ammonium was used as an additive as with the other substrates, the coupling performed better and faster in the presence of a crown ether, the best one being DCH-18-C-6, with good yields and low reaction times. This method would provide a direct access to novel structures of biological interest.