J. Zeevaart, C. Parkinson, C. B. Koning
May 24, 2004
Citations
0
Influential Citations
40
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K 3 PO 4 is described. The arylated acetoacetate ester is de-acylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters.