Samir A. Al-taweel, Salah A Al-Trawneh, Wal'A M. Al-Trawneh
Jan 1, 2019
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Journal
Cogent Chemistry
Abstract
Abstract A series of ethyl 7-cyclopropyl-2-(arylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (9a-d) were prepared by coupling of ethyl 7-cyclopropyl-2-chloro-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (8) with primary aromatic amines via palladium-catalyzed amination using palladium acetate Pd(OAc)2 in the presence of cesium fluoride in good yields. The new compounds were characterized by 1H-NMR, 13C-NMR, mass spectrometry, high resolution mass spectrometry and elemental analysis. 7-cyclopropyl-2-(phenylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid (10a) showed weak activity against E.aerogenas and S.aureus bacteria.