B. Maes, Kristof T. J. Loones, T. Jonckers
Dec 1, 2002
Citations
0
Influential Citations
24
Citations
Journal
Synlett
Abstract
Regioselective palladium-catalyzed aminations with anilines on 2-chloro-3-iodo- and 2-chloro-5-iodopyridine have been performed with excellent yields and good selectivity. The use of a large excess of Cs 2 CO 3 in combination with Pd-BINAP catalyst was essential to obtain sufficiently fast reactions. The mild conditions permit the presence of base sensitive functional groups. Moreover, the catalytic system developed also allows the arylamination of aryl iodides.