Ziwei Hu, Dongdong Liang, Jiaji Zhao
Jun 27, 2012
Citations
0
Influential Citations
67
Citations
Journal
Chemical communications
Abstract
A base-controlled synthesis of 2-substituted secondary and tertiary 1H-indole-3-carboxamides through PdCl(2)-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion has been developed. The reaction proceeds smoothly at ambient temperature using O(2) in air as the sole oxidant of the palladium catalyst.