Qihua Zhu, Dezhong Ji, Tingting Liang
Jul 14, 2015
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Influential Citations
54
Citations
Journal
Organic letters
Abstract
A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids.