Qizhong Zhou, Bin Zhang, Liangjun Su
Dec 23, 2013
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron
Abstract
Abstract 2,3- and 2,5-Dibromopyridines reacted with arylboronic acids, catalyzed by Pd(OAc) 2 /PPh 3 in the presence of K 2 CO 3 in CH 3 CN/MeOH (2:1) at 50 °C for 24 h, to afford 2-arylpyridines in good to high yields, while 2,4-dibromopyridine reacted with arylboronic acid pinacol esters, catalyzed by Pd(OAc) 2 /PPh 3 in the presence of KOH in CH 3 CN at 70 °C for 24 h, to afford 2-arylpyridines in good to high yields. To expand this methodology, a 17β-HSD1 inhibitor was synthesized in good yield.