Chao-Yuan Chen, Pinhong Chen, Guosheng Liu
Dec 10, 2015
Citations
1
Influential Citations
101
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Quality indicators
Journal
Journal of the American Chemical Society
Abstract
The first catalytic trifluoromethoxylation of unactivated alkenes has been developed, in which Pd(CH3CN)2Cl2 was used as catalyst, AgOCF3 as trifluoromethoxide source, and Selectfluor-BF4 as oxidant. A variety of 3-OCF3 substituted piperidines were selectively obtained in good yields. Direct evidence was provided to address the facile reductive elimination of Pd(IV)-OCF3 complex to form sp(3) C-OCF3 bond.