A. Bom, S. Booth, J. Bruin
Sep 3, 2001
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The first solid-phase synthesis of zatebradine 1 and its analogues is reported. This has resulted in the preparation of compounds with increased ability to reduce the spontaneous beating of isolated guinea-pig atria in a concentration-dependent manner. One example, 8g, showed a maximum reduction of beating of 80% at 3 microM compared to a reduction of 40% at 3 microM with zatebradine 1.