S. Just, K. Arndt, T. Weiser
Sep 1, 2006
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Influential Citations
11
Citations
Journal
Drug Discovery Today: Disease Mechanisms
Abstract
Migraine is a common debilitating neurovascular disorder. Because of their dual role in modulating neuronal and vascular events, neuropeptides have been implied to be of importance in migraine pathophysiology. Most clinical trials investigating neuropeptide receptor ligands for the treatment of migraine, however, did not show the desired results. The only exception so far is Olcegepant (BIBN4096BS), a potent and selective antagonist of the calcitonin gene related peptide (CGRP) receptor. In a clinical study, this compound proved to be effective in treating migraine headache, highlighting the essential role of CGRP for pathophysiology of migraine.