T. Andus, F. Klebl, G. Rogler
Feb 1, 2003
Citations
0
Influential Citations
47
Citations
Journal
Alimentary Pharmacology & Therapeutics
Abstract
Background : Dehydroepiandrosterone is a steroid hormone used as an ‘over‐the‐counter’ drug in the USA. Treatment with dehydroepiandrosterone was effective in randomized controlled trials in patients with systemic lupus erythematosus. Dehydroepiandrosterone sulphate concentrations are decreased in patients with inflammatory bowel disease. Dehydroepiandrosterone inhibits nuclear factor‐κB and the secretion of interleukin‐6 and interleukin‐12 via the peroxisome proliferator‐activated receptor α.