Yukitoshi Takahashi, Yoshikazu Yamamoto, Kosuke Katagiri
Sep 23, 2005
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0
Influential Citations
44
Citations
Journal
The Journal of organic chemistry
Abstract
[reaction: see text] (S)-2-(tert-Butylmethylphosphino)phenol and its methyl ether were synthesized from tert-butyldichlorophosphine via optically active phosphine-boranes as the intermediates. The former compound was used as a P/O hybrid ligand in the Cu-catalyzed asymmetric conjugate addition of diethylzinc to acyclic enones to achieve high enantioselectivity of up to 96%.