M. Wasa, Brady T. Worrell, jin-quan yu
Feb 8, 2010
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Influential Citations
186
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Journal
Angewandte Chemie
Abstract
The first example of C-H functionalizations of pyridine rings at the 3- and 4-positions is developed using Pd(0)/PR3/ArBr. This reaction provides a powerful method for the preparation of structurally diverse nicotinic and isonicotinic acids that are of tremendous importance in drug discovery.