Hongban Zhong, Dan Yang, Songqing Wang
Feb 29, 2012
Citations
2
Influential Citations
136
Citations
Quality indicators
Journal
Chemical communications
Abstract
An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described.