V. Chan, R. Bergman, F. Toste
Nov 16, 2007
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Journal
Journal of the American Chemical Society
Abstract
Palladium-catalyzed cross-couplings represent a powerful method for the formation of new bonds. A catalytic, enantioselective P−C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N,N-diisopropylbenzamides.