Xuning Wang, Song-Yang Niu, Lanting Xu
Jan 6, 2017
Citations
1
Influential Citations
27
Citations
Journal
Organic letters
Abstract
A short and efficient synthesis of (S)-N-Boc-2,6-dimethyltyrosine utilizing palladium-catalyzed directed C-H functionalization is described. This represents the first general method for the ortho-dimethylation of tyrosine derivatives and offers a practical approach for preparing this synthetically important building block. Notably, throughout the reaction sequence no racemization occurs at the susceptible α-chiral centers.