M. Rao, Abhijeet Kumar
Sep 30, 2014
Citations
0
Influential Citations
23
Citations
Journal
Tetrahedron
Abstract
Abstract Cross-coupling reactions of differently substituted 4-chlorocoumarins were studied under palladium catalysis using triarylbismuths as threefold arylating reagents. The high reactivity of 4-chlorocoumarins was demonstrated delivering mono- and bis-arylation products in a chemo-selective manner. The reaction conditions employed are simple, robust and the threefold coupling reactivity of triarylbismuth reagents was witnessed with good to high yields in 2–4 h conditions. The utility of the methodology was explored in the synthesis of a few natural occurring neoflavones ( 3.27 – 3.30 ). In addition, the 4-arylcoumarin 3.1 product is a useful precursor for the preparation of ( R )-tolterodine.